Ian Gizer

Ian Gizer
Associate Professor
gizeri@missouri.edu
Research Interests

My research focuses primarily on understanding the genetic influences that contribute to the development of externalizing spectrum disorders, including disorders of childhood such as attention-deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder as well as disorders of adolescence and adulthood such as drug and alcohol abuse and dependence and antisocial personality disorder. Further, I am interested in examining how correlates of these disorders, such as aspects of personality, cognitive deficits, and co-occurring disorders, can be used to refine our understanding of the genetic contributions to their development in a manner that will further our overall understanding and classification of these disorders.

Education
  • Ph.D. in Clinical Psychology, Emory University
  • M.A. in Clinical Psychology, Emory University
  • B.A. in Psychology, University of California, Berkeley
Awards
  • Max Meyer Outstanding Junior Faculty Research Award, Department of Psychological Sciences, University of Missouri (2015)
  • Junior Investigator Travel Award, Research Society on Alcoholism Annual Meeting (2009)
  • Student Travel Award, Molecular Genetics of Attention Deficit/Hyperactivity Disorder International Consortium – Brussels, Belgium (2006)
  • Student Travel Award, Molecular Genetics of Attention Deficit/Hyperactivity Disorder International Consortium – Miami, FL (2005)
  • Irwin J. Knopf Award, best student presentation at a conference, Department of Psychology, Emory University, May 2003
  • Student Travel Award, Molecular Genetics of Attention Deficit/Hyperactivity Disorder International Consortium – Boston, MA (2003)
  • Student Travel Award, Molecular Genetics of Attention Deficit/Hyperactivity Disorder International Consortium – Dublin, Ireland (2002)
Publication

Gizer, I.R., Bizon, C., Wilhelmsen, K.C., Gilder, D.A., Ehlers, C.L. (2017). Whole genome sequence study of cannabis dependence in two independent cohorts. Addiction Biology, online version ahead of print 

Otto, J.M., Gizer, I.R., Deak, J.D., Fleming, K.A., Bartholow, B.D. (2017). A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcoholism: Clinical and Experimental Research, 41, 929-938.

Richmond-Rakerd, L., Otto, J.M., Slutske, W.S., Ehlers, C.L., Wilhelmsen, K.C, & Gizer, I.R. (2016). A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May Be Differentially Associated with Cigarettes per Day and Tobacco-Related Problems. Tobacco & Nicotine Research, 19, 426-434.

Otto, J.M., Gizer, I.R., Ellingson, J.M., Bizon, C., Wilhelmsen, K.C., Ehlers, C.L. (2016). Polygenic risk scores for cigarettes smoked per day do not generalize to a Native American population. Drug and Alcohol Dependence, 167, 95-102.

Gizer, I.R. (2016). Molecular genetic approaches to understanding comorbidity of psychiatric disorders. Development & Psychopathology, 28, 1089-1101.

Gizer, I.R., Otto, J.M. Ellingson, J. (2015). Molecular Genetic Approaches to the Study of the Externalizing Spectrum. To appear in T. Beauchaine & S. Hinshaw (Eds.), Oxford Handbook on Externalizing Spectrum Disorders (pp. 125-148). Oxford University Press.

Peng, Q., Gizer, I.R., Libiger, O., Bizon, C., Wilhelmsen, K.C., Schork, N.J., & Ehlers, C.L. (in press). Association and ancestry analysis of ADH and ALDH variants with alcohol-related phenotypes in a Native American community sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

Norden-Krichmar, T.M., Gizer, I.R., Libiger, O., Wilhelmsen, K.C., Ehlers, C.L. (2014). Correlation analysis of genetic admixture and social identification with body mass index in a Native American community. American Journal of Human Biology, 26, 247-260. PMID: 24757035

Criado, J.R., Gizer, I.R., Edenberg, H.J., Ehlers, C.L. (2014). CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women. Twin Research and Human Genetics, 17, 80-88. PMID: 24588897

Bizon, C., Spiegel, M., Chasse, S.A., Gizer, I.R., Li, Y., Malc, E.P., Mieczkowski, P.A., Sailsbery, J.K., Wang, X., Ehlers, C.L., Wilhelmsen, K.C. (2014). Variant calling in low-coverage whole genome sequencing of a Native American population sample. BMC Genomics,15:85. doi: 10.1186/1471-2164-15-85. PMID: 24479562

Gizer, I.R., Gilder, D.A., Lau, P., Wang, T., Wilhelmsen, K.C., Ehlers, C.L. (2013). Contributions of ethnicity to differential item functioning of cannabis abuse and dependence symptoms. Journal of Studies on Alcohol and Drugs, 74, 320-328. PMID: 23384380

Ehlers, C.L. & Gizer, I.R. (2013). Evidence for a genetic component for substance dependence in Native Americans. American Journal of Psychiatry, 170, 154-164. PMID: 23377636

Gizer, I.R. & Waldman I.D. (2012). Double Dissociation between Lab Measures of Inattention and Impulsivity and the Dopamine Transporter Gene (DAT1) and Dopamine D4 Receptor Gene (DRD4). Journal of Abnormal Psychology, 121, 1011-1023. PMID: 22564179

Gizer, I.R., Ehlers, C.L., Vietan, C., Feiler, H.S., Gilder, D.A., & Wilhelmsen, K.C. (2012). Genome-wide linkage scan of antisocial behavior, depression, and general substance misuse in the UCSF Family Alcoholism Study. Psychiatric Genetics, 22, 235-244. PMID: 22517380

Gizer, I.R., Ehlers, C.L., Vietan, C., Seaton-Smith, K.L., Feiler, H.S., Lee, J.V., Segall, S.K., Gilder, D.A., & Wilhelmsen, K.C. (2011). Linkage scan of nicotine dependence in the UCSF Family Alcoholism Study. Psychological Medicine, 41, 799-808. PMID: 20594377

Gizer, I.R., Ehlers, C.L., Vietan, C., Seaton-Smith, K.L., Feiler, H.S., Lee, J.V., Segall, S.K., Gilder, D.A., & Wilhelmsen, K.C. (2011). Linkage Scan of Alcohol Dependence in the UCSF Family Alcoholism Study. Drug and Alcohol Dependence, 113, 125-132. PMID: 20817416

Gizer, I.R., Seaton-Smith, K.L, Ehlers, C.L., Vietan, C. & Wilhelmsen, K.C. (2010). Heritability of MMPI-2 scales in the UCSF Family Alcoholism Study. Journal of Addictive Diseases, 29, 84-97.

Ehlers, C.L., Phillips, E., Gizer, I.R., Gilder, D.A., and Wilhelmsen, K.C. (2010). EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study. Drug and Alcohol Dependence, 106, 101-110. PMID: 19748744

Ehlers, C.L., Gizer, I.R., Vieten, C., Gilder, D.A., Finnerman, G., Lau, P., & Wilhelmsen, K.C. (2010). Cannabis dependence in the San Francisco Family Study: Age of onset of use, DSM-IV symptoms, withdrawal, treatment, and heritability. Journal of Addictive Behaviors, 35, 102-110. PMID: 19818563

Gizer, I.R., Ficks, C. & Waldman, I.D. (2009). Candidate Gene Studies of ADHD: A meta-analytic review. Human Genetics, 126, 51-90. PMID: 19506906

English, B.A., Hahn, M.K., Gizer, I.R., Mazei-Robison, M., Steele, A., Kurnik, D.M., Stein, C.M., Stein, M.A., Waldman, I.D., & Blakely, R.D. (2009). Choline transporter gene variation supports Attention-Deficit Hyperactivity Disorder. Journal of Neurodevelopmental Disorders, 1, 252-263.

Gizer, I.R., Waldman, I.D., Abramowitz, A., Barr, C.L., Feng, Y., Wigg, K., Misener, V., & Rowe, D.C. (2008). Relations between multi-informant assessments of ADHD symptoms and DAT1 and DRD4. Journal of Abnormal Psychology, 117, 869-880. PMID: 19025233

Waldman, I.D., Gizer, I.R., Nigg, J., Friderici, K., Park, L., & Rappley, M. (2006). The adrenergic receptor 2-α gene (ADRA2A) and endophenotypes for childhood ADHD. Cognitive, Affective, and Behavioral Neuroscience, 6, 18-30. PMID: 16869226

Kim, C.-H., Hahn, M.K., Joung, Y., Steele, A.H., Cohen, B.M., Robertson, D. Waldman, I.D., Gizer, I.R., Blakely, R.D., & Kim, K.-S. (2006). A novel polymorphism in the human norepinephrine transporter gene alters promoter activity and associated with attention deficits. Proceedings of the National Academy of Sciences, 103, 19164-19169. PMID: 17146058